Raising awareness of sexual health on National STIQ Day

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Raising awareness of sexual health on National STIQ Day

National STIQ Day

National STIQ day was introduced in 2010 and every year since then the 14th of January has been dedicated to raising awareness for STIQ.  The purpose is to emphasize the importance of sexual health and to encourage everyone to get regular health checks.

Sexually Transmissible Infections (STIs) are infections passed from one person to another through unprotected vaginal, oral, or anal sex, or genital contact.

Lack of symptoms

More and more people in the UK are catching STIs and each year the infection rate is rising. According to The World Health Organization (WHO), more than 1 million STIs are acquired every day and the majority of these STIs have no symptoms.1 Therefore you could have an STI and not be aware. 70% of women and 50% of men show no symptoms after contracting Chlamydia which is the most common STI condition in the UK.

Even though the majority of the time symptoms of STIs aren’t visible, there can be signs of having an STI, including unusual discharge from the vagina, penis or anus, pain when peeing, lumps or skin growth around the genitals, a rash, unusual bleeding, itchiness or blisters around the genitals.3

What to do when you catch an STI

Anyone can catch an STI regardless of what age you are, your sexuality or how many sexual partners you have, as it only takes one sexual encounter to put you at the risk of catching an STI. A shocking fact from Public Health England shows that a case of chlamydia or gonorrhea is diagnosed in a young person every 4 minutes in England, and over 144,000 diagnoses of these sexually transmitted infections are seen in people aged 15 to 24 in 2017. 4

It is extremely important to get routinely tested. The earlier the diagnosis is made and treated the less chance of having long-term effects including infertility.

Randox Biosciences 10-plex STI test

Randox Biosciences would like to take the opportunity to support STIQ day by offering our CE marked 10-plex STI test, a cost-effective solution for accurate STI testing. This test detects the following 10 infections simultaneously from a single patient urine sample.

  • Neisseria gonorrhoea (NG)
  • Mycoplasma genitalium (MG)
  • Ureaplasma urealyticum (UU)
  • Chlamydia trachomatis (CT)
  • Trichomonas vaginalis (TV)
  • Haemophilus ducreyi (HD)
  • Mycoplasma hominis (MH)
  • Treponema pallidum (TP)
  • Herpes simplex virus 1 (HSV-1)
  • Herpes simplex virus 2 (HSV-2)

Does your laboratory or clinic carry out STI testing? Our molecular analyser, the Bosch Vivalytic, powered by our award winning Biochip Array Technology, could be the diagnostic solution.

For more information about our STI Arrays or Vivalytic email: info@randoxbiosciences.com

  1. https://www.who.int/news-room/fact-sheets/detail/sexually-transmitted-infections-(stis)
  2. http://www.national-awareness-days.com/stiq-day/
  3. https://www.gov.uk/government/news/an-sti-is-diagnosed-in-a-young-person-every-4-minutes-in-england
  4. https://www.nhs.uk/conditions/sexually-transmitted-infections-stis/

 

 

 


Discussing Companion Diagnostics with Dr Miguel Quesada-González

You may have heard of Companion Diagnostics. This type of diagnostic provides information that is essential for the safe and effective use of a corresponding drug or biological product. It can help to stratify groups of patients which will respond safely to a clinical drug trial, and those who may suffer undesirable side effects.

But why are Companion Diagnostics useful?

Randox Biosciences Pharma Relationship Manager Dr Miguel Quesada-González, PhD has the answer.

“As part of my new role, I’ll be supporting drug development and clinical trials. So as a scientist by background (the nature of the beast) I’ve been reading into and researching this incredibly interesting area of science.

“Since Day 1, Companion Diagnostics (CDx) especially caught my eye.

“When it comes to new drug development, either for Pharma or Biotech, there are many benefits of running a CDx. Based on well-acknowledged scientific papers that I have read, and my own personal perception of the current situation, I’d like to summarise and simplify in just 2 bullet points, what I personally believe to be the most important benefits of running a CDx.

“(a)  Delivering the right treatment to the right patient at the right time.

“We should never forget that our priority is the health and integrity of patients. It’s been proven that patients who have similar diagnoses very often respond differently to the same treatment. This variability presents a risk in both the efficacy of the treatment and the safety of the patient.

“The development of a drug is already a risky, long and costly process, so wouldn’t you like to avoid the initial high risk by having a good defined target initially?

“(b)  Saving time.

“Money is valuable but time even more so. Time is precious and priceless. Once it’s gone, there’s nothing we can do about it!

“The smaller and more targeted the clinical trials are, the less time and resources you’ll be spending. Normally, the CDx is not initiated until a drug has reached the later stages of development, but, actually, if you put the CDx in place at early development stages (preclinical) it presents many advantages because it enables the selected biomarker to be validated and determined before large amounts of resources have been put in place.

“The faster a potential treatment is developed and approved, the more people you can save, cure or simply improve their quality of life.”

For further information on Companion Diagnostics from Randox Biosciences please email us at info@randoxbiosciences.com

Dr Miguel Quesada-González, PhD, Randox Biosciences Pharma Relationship Manager

 

 

 

 

 


The Evidence Evolution – The newest member of the Evidence series

Launched in 2016, the Evidence Evolution has set new standards in the world of clinical, forensic and food testing.

With the most extensive test menu on offer, we can provide more tests than any other supplier and we are continually investing in R&D to keep up with industry developments and challenges, such as our extensive clinical test menu with a range of routine and novel tests including our CKD panel which detects the early stages of Chronic Kidney Disease.

The Evidence Evolution utilises Randox’s cutting-edge Biochip Array Technology, offering diagnostic testing from a single sample. The Evidence Evolution boasts 2640 tests per hour and when put to the test against our competitor machines, the Evidence Evolution gives a true walk away time of up to 2 hours, meaning staff can fully load the machine and get up to 44 results from each sample every minute, while they get on with important laboratory tasks.

The Evidence Evolution has been designed to meet the needs of a variety of laboratories. Delivering quality results, efficiently and economically in forensic and clinical immunoassay locations.

The Evidence Evolution is the latest development in our Evidence Series range, which was first launched in 2002. This trusted technology is powered by Biochip and is used throughout the world in a range of different sites for clinical, toxicology and food testing. The Evidence Series has a range of analysers that can meet the need of any laboratory.

For more information on any of the Evidence Series analysers, please visit https://www.randox.com/evidence-series/ or contact us evidenceseries@randox.com.

 

 

 

 


Your outsourcing solution enhanced by Randox Biochip Array Technology

Randox Clinical Laboratory Services (RCLS) strives to provide a clinical laboratory service to meet the time sensitive, bespoke requirements of research and clinical projects globally.

RCLS utilises the expertise and knowledge Randox has built up over 35 years producing high quality IVD products. Many years of development and the expertise of highly qualified scientists from Randox has been invested to create the Biochip Array Technology (BAT) – a multi-analyte testing platform facilitating the simultaneous quantitative or qualitative detection of a wide range of analytes from a single sample.

Biochip Array Technology provides a unique platform for assessment of biological samples in a rapid, accurate and easy to use format and users can have the utmost confidence in this proven technology.

A chemically activated 9x9mm ceramic biochip acts as a solid phase reaction vessel. Biochips are pre-fabricated with discrete test regions (DTRs); a different antibody/oligonucleotide is immobilised at each spatially distinct DTR. Up to 49 individual DTRs can be arrayed on to a single biochip with one biochip per sample used to generate multiple results simultaneously.

This eliminates the need to run costly, time consuming and sample intensive single analyte assays. The biochip detection is based on a chemiluminescent signal emitting light, without heat, as a result of a chemical reaction. The light emitted is simultaneously detected and quantified using a CCD camera.

Overall, by utilising Randox Clinical Laboratory Services you can save your laboratory time and money. Due to our multiplex panels we offer a cost-effective, labour-saving and time-reducing solutions for your sample testing. As a result we provide your laboratory with the best solution to outsource your sample.

If you would like to find out more information about RCLS you can visit www.randox.com/rcls

Or for any additional questions on what it has to offer you can email the RCLS team at info@rcls.com

 

 

 

 


Is Biomarker Multiplexing the future of kidney disease screening?

Chronic Kidney Disease (CKD) is both a cause and a consequence of cardiovascular diseases, and is an increasing burden on global health. As diabetes, obesity and hypertension incidences continue to rise and the world’s population steadily ages, CKD’s prevalence is already estimated to be between 11% and 13% globally for all five KDOQI stages, with a majority in Stage 3 (about 90% of all stages).

With early stages of CKD being asymptomatic and current diagnostic tools (proteinuria determined by albumin to creatinine ratio and decreased renal function estimated from GFR using the CKD-EPI equation) are insufficiently sensitive to detect most cases up to stage 3, it is likely that the true prevalence of CKD is still underestimated. Therefore the need to improve both early diagnostics and overall CKD outcome is all the more critical.

Accordingly, biomarker research has been intense in the field of renal disease for at least 10 years with a number of promising candidates emerging, some now well-known by specialists: Cystatin C, NGAL or KIM-1 for example.

However, further novel biomarkers, assessed in combination using a properly developed multiplex assays can allow superior insight into CKD than what their individual performance could achieve.  This also largely stems from selecting the markers that are indicative of complementary mechanisms that contribute to the development of CKD.

When assayed together from a single serum sample and after combinatorial analysis has been applied, these biomarkers can open new avenues in the management of CKD, such as proper diagnosis of the condition from Stage 1, clear differentiation between stages and monitoring of the progression pace of the disease. Early screening of patients at risk of CKD is now within reach and it is expected that its systematic use will have a profound impact on health system economics.

Another area of interest in renal research is Acute Kidney Injury (AKI) which may arise as a result of cardiac surgery and can subsequently lead to CKD. AKI detection is also of significant interest in the field of drug development, where early stage toxicity is still a large cause of new drug marketing withdrawal. Hence selecting and qualifying kidney tissue damage biomarkers, and assembling them into a multiplex panel is a key priority to those involved in early stage clinical trials.

An AKI panel has been worked out using the same principles as those used in the development of the CKD panel: high individual diagnostic value and multiple, independent cellular targets. This panel is now ready for final clinical qualification and will be one of the first of several organ-targeted safety panels aiming to become standard for drug induced toxicity screening.

It is key to the adoption of multiplex testing that proper validation guidelines be published and that careful, matrix-based validation data is made available to potential users. It is essential that multiplexed testing comes to the front line of testing in the field, so it can deliver to its full potential and start translating into public health improvement and cost savings. Technology is ready, let’s make a start!

Dr Claire Huguet

Randox Biosciences – Head of Biomarkers

 

For further information about kidney disease screening from Randox Biosciences, please contact randoxpr@randox.com

 

 

 


Randox Clinical Laboratory Services: Your STI Outsourcing Solution

Have you heard about our latest offering? Randox Clinical Laboratory Services now offers a multiplex Sexually Transmitted Infection Array testing service allowing your clinic, laboratory or GP practice to outsource sample STI testing.

Our STI array is the broadest multiplex test on the market, simultaneously detecting 10 bacterial, viral and protozoan infections. It consists of  the following most common STIs, Chlamydia, Gonorrhoea, Syphilis, Herpes Simplex I, Herpes Simplex II, Trichomonas Vaginalis, Mycoplasma Hominis, Mycoplasma Genitalium, Ureaplasma Urealyticum and Chancroid. This simultaneous detection is made possible by our patented and innovative Biochip Array Technology which utilises multiplex testing methodology in a rapid and accurate format.

There are many benefits to outsourcing your STI samples with RCLS, which include:

  • CE-marked
  • ISO17025 Accredited Laboratories
  • Excellent precision, specificity, sensitivity and accuracy for STI diagnosis
  • Reduced risk of false reporting and a reduced number of unnecessary confirmatory tests
  • Smaller sample volumes are required, enabling faster throughput and rapid patient diagnosis

The type of sample which should be sent to our RCLS lab is determined by the visibility of the patient’s symptoms.

Non-visible symptoms – urine sample required.

Visible symptoms – swab sample required.

The process for sending STI samples to Randox Clinical Laboratory Services is simple and easy to follow. Georgia Roberts, our RCLS representative will guide you through the process from your initial enquiry to pricing and shipment of samples.

All RCLS laboratories utilise our world class clinical chemistry analysers, the RX Series, along with our multiplex immunoassay analysers, the Evidence Series. We also perform sample testing on numerous third party analysers situated in our laboratories dependent upon the testing which is required by the customer.

RCLS incorporates multiple laboratories across the United Kingdom including our state-of-the-art facility in Antrim, as well as further laboratories in Belfast, Liverpool and London. RCLS is ever expanding with plans to open another facility in Los Angeles.

Overall, by utilising Randox Clinical Laboratory Services you can save your laboratory time and money. Due to our multiplex panels we offer a cost effective, labour saving and time reducing solutions for your STI testing. Providing your laboratory with the best solution to outsource your samples.

If you would like to find out more information about RCLS and what it has to offer contact info@rcls.com

 

 

 


Sir AP McCoy and father of late “King of Heswall” team up for Randox Health Week

Almost a year to the day of the tragic death of the “King of Heswall” Tim Cogley, his father will be joined by some of the UK’s best-known sports stars at an event in Liverpool to raise awareness of how lives can be saved through improving access to earlier routine health screening.

On April 9th 2017 Tim, who was only 34-years old, suffered a fatal heart attack due to a genetic condition which could have been managed had it been diagnosed earlier. It spurred his father, Frank Cogley, to set up a charity to raise awareness of the importance of health checks for young people.

He’ll be joined at the free Randox Health Week event in Exchange Station on 11th April by legendary jockey Sir AP McCoy, champion boxer Paul Smith and Olympic sailor Matt McGovern. The public will be invited to join the discussions as well.

Frank said: “It’s been recently reported that at least 12 under-35s die from undiagnosed heart conditions every week in the UK. The current lack of routine screening of 18-40-year olds leaves a gaping chasm in our healthcare provision. With our highly motivated partners, through events like this, we hope to redress this through lifestyle changes and preventative medical programmes. The ‘Tim Cogley Cardiac Screening Foundation’ is committed to delivering positive, action-focused and life-changing programmes. I can’t imagine a legacy more in tune with the generous, kind and supportive person that was Tim!”

This is the second year that Randox Health Week has been held in the city. The areas of mental health and active cities will be explored on days one and two – the 9th and 10th respectively. On each of the mornings, local athletes Franny Norton and Derry Mathews will be putting pupils to the test with a range of sporting activities at LJMU’s Byrom Street campus.

By working with the city’s leading universities – Liverpool John Moores and Liverpool Hope – cutting-edge innovations in healthcare and emerging trends are being shared with a global audience. One such ground-breaking development is a test for prediabetes which is key to tackling the worldwide threat of preventable cases of Type-2 diabetes. It’s something that legendary jockey Sir Anthony McCoy, also taking part in Wednesday’s talk, has first-hand experience of:

“When I got my first test results back that said I had prediabetes, it floored me. I had never imagined that I, someone who had been a professional athlete all of my life, could develop it. It just goes to show that we’re all vulnerable. I only wish it had been around when it could have helped my mum who lived with Type-2 diabetes for many years. As daunting as it was getting the diagnosis, it’s been empowering to very simply make lifestyle changes to reverse it. This needs to be accessible to everyone – it needs to be on the national diabetes screening programme.”

Dr Peter FitzGerald, Managing Director of Randox Health, commented: “The themes we’re focusing on this week are some of the most important global concerns facing us today – mental health, physical activity and showing people the benefits to being proactive about their health, rather than facing the consequences of preventable sickness. You need look no further than Frank Cogley who is working tirelessly to turn his son’s tragic death into a force for good to see how important this is. With the support from AP McCoy and Paul Smith, we hope this event will inspire many people in the city and beyond.”

Tickets are free and can be reserved at www.eventbrite.co.uk/e/randox-health-week-2018-tickets-43648350391

For further information about Randox Health Week, please contact the Randox PR team by email: randoxpr@randox.com or by phone: 028 9442 2413

 

 

 

 


Biochip Carrier Applications in the Randox Evidence Series

Biochip Array Technology is the fundamental component which drives the Randox Evidence Series immunoanalysers. The simultaneous detection of multiple analytes from a single sample allows for a complete patient profile, providing exceptional time, resource and cost savings.

The Evidence Series analysers all carry the Biochip in different applications. In order to gain a better understanding of how it is utilised, the illustrations below demonstrate how adaptable and flexible the technology is across the Evidence Series.

Evidence Evolution

  • One strip contains 10 biochips
  • Analyser can hold 20 strips
  • Can produce a throughput of up to 2640 tests per hour

Evidence

  • Each cassette contains 10 carriers
  • Each carrier has 9 wells
  • Analyser can hold 4 cassettes at once
  • Can produce a throughput of up to 3960 tests per hour

 Evidence Investigator

  • Analyser holds 1 cartridge
  • 1 cartridge contains 9 wells
  • Thermoshaker capable of carrying 6 cartridges
  • Can produce a throughput of up to 2376 tests per hour

 Evidence MultiSTAT

  • Analyser holds 1 cartridge
  • Cartridge comes pre-loaded with reagents and QC
  • Can produce a throughput of up to 132 tests per hour

 

About the Randox Evidence Series

The Evidence Series is set to revolutionise diagnostic testing forever. Offering unrivalled capabilities across all analysers, we truly believe that the Evidence Series range of immunoassay analysers can meet your diagnostic testing capabilities.

For more information on any of the Evidence Series analysers, visit https://www.randox.com/evidence-series/ or contact us evidenceseries@randox.com.

 

 

 


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