Vivalytic: The all-in-one solution for Molecular Diagnostics

Vivalytic: The all-in-one solution for Molecular Diagnostics

A game-changing partnership between Randox Laboratories and Bosch is changing the accessibility to molecular diagnostics with the launch of a revolutionary product – the innovative platform Vivalytic.

Using Randox-patented Biochip Array Technology, it is the easiest-to-use and most-comprehensive multiplex PCR platform on the market. It provides the broadest range of test options ever seen for an analyser of its size, and also supports single-plex and low-plex testing, simplifying the processes for otherwise-complex laboratory test procedures. Depending on the test application, results will be delivered from 30 minutes.

Biochip Array Technology, developed by Randox Laboratories, is the innovative multiplexing technology which is utilised within the cartridge aspect of the platform. The Biochip allows for the simultaneous detection of multiple analytes from a single sample.

The new platform will be initially released with two molecular arrays available including Respiratory Tract Infection and Sexually Transmitted Infection with other tests to follow.

The Vivalytic is the perfect fit for any laboratory with numerous benefits to enhance your laboratories testing capabilities.

 

Hygienic and space saving

No other peripherals such as laptop, keyboard, barcode scanner or filling stations are required. This makes Vivalytic a hygienic and space-saving all-in-one solution.

 

Direct and clear results

The test result is presented clearly in a summary, but also details on the raw data of each individual measurement can be displayed.

 

Protected system

The Vivalytic integrates the software with the instrument to ensure a safe and reliable run. This is the ultimate protection of the data and the valuable sample material.

 

Networked and combinable

Easy integration with popular standard IT systems makes test results instantly available. An analyser device can be networked and combined with several other devices so that multiple series of tests can be performed simultaneously. All devices are based on the same hardware and software, so that the product family can be expanded quickly and without major development effort.

 

28th European Congress of Clinical Microbiology and Infectious Diseases

Randox Laboratories will be attending the 28th European Congress of Clinical Microbiology and Infections from the 21st – 24th April 2018.

 

Our innovative diagnostic solutions have been developed with consolidation and economy in mind, providing cost savings whilst using pioneering technology.

 

Diagnostics is our passion. We are dedicated to developing solutions that not only meet your needs, but are of the highest quality, the most reliable and the most cost-effective. We look forward to meeting you in Madrid at IFEMA – Feria de Madrid to launch the Vivalytic at our stand 55A.

 

For further information, visit https://goo.gl/S2Yj2c or email info@randoxbiosciences.com

 

 

 


GPs are told to stop prescribing antibiotics for sore throats

Today, the National Institute for Health and Care Excellence has published guidelines that state doctors should not prescribe precious antibiotics for most people with sore throats and should instead recommend drugs like paracetamol.

The guidelines from NICE and Public Health England, which aim to limit the use of antibiotics, said doctors should only be prescribing the medicines for more severe cases that are most likely to have been caused by a bacterial infection.

This is despite recent research that suggests antibiotics are prescribed in 60% of sore throat cases, for which doctors are unable to tell if the infection is viral or bacterial.

The National Institute for Health and Care Excellence said most sore throats were caused by viral infections, which cannot be treated by antibiotics.

At Randox, our pioneering R&D teams have developed a revolutionary swab test for respiratory infections which indicates the cause of the infection and whether a patient needs antibiotics or not. This helps to limit the number of patients who are prescribed antibiotics unnecessarily.

The Randox test, which can rapidly detect and identify the cause of 21 respiratory infections in just 5 hours, assists the clinician in prescribing the appropriate antibiotic.

John Lamont, Lead Scientist at Randox Laboratories, said;

“Current diagnostic testing for respiratory infections takes at least 36 hours to confirm the nature of an infection, and they cannot name and categorise infections as bacterial or viral in the way our new respiratory test can.”

This test, if widely adopted, could allow medical practitioners to make the correct treatment choice on the same day as examination and before patients have already begun a precautionary course of inefficient antibiotics.  It would also have additional efficiency savings for the NHS, by eliminating the need for lengthy microbiology lab tests and unnecessarily prescribing drugs which are not needed.

This new rapid and accurate test will give clinicians confidence in their diagnosis of respiratory infections and will allow for quicker treatment if necessary, which benefits patient outcomes.

The test is also available as a Randox Health Cough, Cold & Flu offering, and can be carried out by booking an appointment with Randox Health at our clinics in Crumlin, Holywood or London, or by arranging the mobile clinic to visit you at your home or place of work.

Find out more about the Cough, Cold & Flu Respiratory test here.

Book an appointment with one of our clinics, or arrange the mobile clinic, by phoning 0800 2545 130 or by clicking here.

For further information please contact the Randox PR team by email: randoxpr@randox.com or phone 028 9442 2413

 


Evidence Investigator | Adaptable, Efficient & Comprehensive

The Evidence Investigator is a compact, semi-automated benchtop analyser that offers efficient and comprehensive testing across a range of applications including clinical diagnostics, molecular, research, toxicology and food diagnostics.

Renowned for its versatility, robustness and effective reporting methods, the Evidence Investigator has been used in a wide range of laboratory settings for over 15 years. This highly advanced yet simple to use analyser has only one moving part, giving the user peace of mind.

The Evidence Investigator contains a host of innovative on-board data analysis features ensuring manual processes are kept to a minimum.

By utilising the same multiplex technology as the other Evidence Series analysers, the Evidence Investigator can process up to 44 results from a single sample, with a maximum throughput of up to 2376 tests per hour. Offering efficiency without compromising on accuracy, the Evidence Investigator is the perfect fit for medium throughput laboratories seeking maximum use of bench space.

Accurate and Robust

Like all the Evidence Series analysers, what sets it apart is technology. The Evidence Investigator is extremely well equipped to provide reliable results, while simultaneously robust enough to withstand frequent, heavy use.

Results are generated using a Charge Coupled Device (CCD) camera, which quantifies chemiluminescent light. This light measures the degree of binding between the patient sample and specific biochip bound ligands, generating highly accurate and reliable results.

Consolidation

The Evidence Investigator is the world’s first platform allowing consolidation of immunoassay and molecular diagnostics. This is achieved through utilising protein and DNA based biochips. By giving the user the ability to consolidate tests, the Evidence Investigator improves laboratory efficiency and reduces costs.

 Advanced Reporting

The Evidence Investigator image processing software translates light signal generated from chemiluminescent reactions into analyte concentration. This removes the need for any manual processing of data.

Previously unreported tests can also be retrieved, so they can be tested retrospectively. This saves time, labour costs and reduces any reagents wastage. All data is then analysed on-board, removing issues related to human error and result manipulation.

About the Randox Evidence Series

The Evidence Series is set to revolutionise diagnostic testing forever. Offering unrivalled capabilities across all analysers, we truly believe that the Evidence Series range of immunoassay analysers can meet your diagnostic testing capabilities.

For more information on the Evidence Investigator, or any of the Evidence Series analysers, visit https://www.randox.com/evidence-series/ or contact us evidenceseries@randox.com.

 


The Effect of Drug Deliveries and MDMA

A recent report by the Independent discussed how buying drugs has become as easy as buying ice cream. The report comes after experts named London as a city where cocaine is now delivered faster than pizza. According to the NHS, in the UK 2.7 million people between the ages of 16 and 59 took an illicit drug in 2015 and 2016 (roughly one in 12 adults). As a result, the Global Drug Survey are now looking at the impact of encrypted mobile phone messaging services and other methods that have enabled quick drug deliveries.

However, the drug problem is worldwide. In the US, life expectancy has fallen for the second consecutive year amid concerns of increased drug related deaths, the first multi-year drop since 1962 and 1963 according to the US National Centre for Health Statistics (NCHS). The NCHS documented that more than 63,600 US deaths in 2016 were due to drug related overdoses, a number that continues to increase.

MDMA has continued to appear in the news, after the deadly substance was responsible for the recent deaths of multiple teenagers in the UK. Also known as Ecstasy, MDMA is often described as the original designer drug due to its link with the dance culture in the late 80s and early 90s. Randox Toxicology’s DoA II panel tests for common drugs of abuse, including MDMA and generic opioids.

With the use of Biochip Array Technology, we have made multiplex testing capabilities possible. Our level of expertise in toxicology research and development allows us to adapt quickly to the ever-changing drug market influences and develop assays for current and novel drug trends.

Cross Reactivity

Analyte Compound Cross Reactivity %
MDMA MDMA 100
MDEA 321.7
PMMA 23.75
MDA 5.5
d,I,BDB 4.8


Purity is a concern with MDMA, which is regularly sold containing other fatal drugs. Newshub released information from Wendy Allison at KnowYourStuffNZ, who stated that only 20 percent of the drugs they tested in New Zealand contained MDMA. KnowYourStuffNZ’s website advises people to avoid certain pressed pills containing large amounts of MDMA. Theses pills include “Green Guccis”, a rectangular green pill with the Gucci logo and “Yellow Rolexes”, a yellow pill shaped like the Rolex crown logo. The comedown of Ecstasy can cause users to feel depression, whilst long term users can suffer from memory problems and anxiety. The use of the Class A drug has also been linked to liver, kidney and heart problems.

For further information on our DoA II panel and how Randox Toxicology are advancing the future of toxicology, email info@randoxtoxicology.com


Molecular Diagnostics from Randox Biosciences

Our Randox Biosciences division is a trusted partner in supplying quality diagnostic solutions to the Clinical, Life Science, Pharmaceutical, Research and BioPharma industries.

Our molecular product range offers diagnostic, prognostic and predictive solutions across a variety of disease areas including sexually transmitted infections (STI), respiratory tract infection, colorectal cancer, familial hypercholesterolemia (FH) and cardiovascular disease (CVD).

Additionally, we can provide a wide range of assay formats including single nucleotide polymorphisms (SNP) genotyping, pathogen detection and mutation detection. The arrays are optimised for use with the Randox Evidence Investigator semi-automated, medium throughput bench-top biochip analyser.

One test, 10 results.

Our STI multiplex array II simultaneously detects 10 bacterial, viral and protozoan infections including primary, secondary and asymptomatic co-infections for a complete infection profile. The assay is based on a combination of multiplex, PCR and biochip array hybridisation. Innovative PCR priming technology permits high discrimination between multiple targets. A unique primer set is designed for each target which will hybridise to a complimentary oligo-nucleotide probe spotted on a biochip discrete test region (DTR).

The combination of priming and spatially organised biochip array technology enables enhanced specificity of the assay. Analysis can be completed from template DNA through PCR to data readout in less than 6 hours. The array is validated for urine and swab sample matrices with up to 53 patient samples being processed simultaneously. The array is CE marked for routine clinical use.

Our STI Multiplex Array II includes tests for the following STIs;

Neisseria Gonnorrhoea (NG)                                       Mycoplasma Genitalium (MG)

Ureaplasma Urealyticum (UU)                                    Chlamydia Trachhomatis (CT)

Tricomonas Vaginalis (TV)                                            Haemophilus Ducreyi (HD)

Mycoplasma Hominis (MH)                                          Treponema Pallidum (TP)

Herpes Simplex virus I (HSV-1)                                   Herpes Simplex Virus 2 (HSV-2)

Randox Biosciences also offer four additional Molecular arrays.

For more information on our Molecular arrays please contact us by sending an email to Info@randoxbiosciences.com

 

 


Powering the Evidence Series – Biochip Array Technology

In 2002, Randox invented a worlds first; Biochip Array Technology, instantly changing the landscape of diagnostic testing forever. Biochip Array Technology is a multi-analyte platform which provides an unrivalled increase in patient information per sample. Instead of a patient sample needing to be subdivided for each test result, or in some cases re-collected, Biochip Array Technology offers a diagnostic patient profile with each patient sample.

How does it work?

Biochip Array Technology is a precision multiplex testing platform allowing for the simultaneous quantitative or qualitative detection of a wide range of analytes from a single sample.

The biochip detection system is based on a chemiluminescent reaction. This is the emission of light, without heat, as a result of a chemical reaction. An enzyme is used to catalyse the chemical reaction on the biochip which generates the chemiluminescent signal. The light emitted from the chemiluminescent reaction that takes place in each DTR is simultaneously detected and quantified using a Charge-Coupled Device (CCD) Camera.

Each biochip has up to 49 Discrete Test Regions (DTR). This means that up to 44 tests can be carried out simultaneously. The additional DTR are reserved for internal quality control and visual reference, a unique Biochip Array Technology feature.

 

How is the technology applied?

With over £250 million invested into Biochip Array Technology research and development, Randox have launched a range of Biochip Array Technology immunoanalysers – The Evidence Series. This includes the Evidence, the Evidence Evolution, the Evidence Investigator and the Evidence MultiSTAT. Each analyser is developed with boundary pushing engineering, designed to make financial, labour and time savings for the end user.

The Evidence Series has truly revolutionised diagnostic testing forever. Offering unrivalled capabilities across all analysers, we truly believe that the Evidence Series range of immunoassay analysers can meet your diagnostic testing capabilities.

 

For more information on any of the Evidence Series, please visit http://www.randox.com/evidence-series/ or contact us evidenceseries@randox.com.


RCLS – at the cutting edge of laboratory innovation

Randox Clinical laboratory Services (RCLS) is the latest offering from Randox, Built over 35 years of experience producing high quality IVD products, Randox Clinical Laboratory Services (RCLS), is dedicated to providing a clinical laboratory service designed to meet the time sensitive, bespoke requirements of research and clinical projects globally.

RCLS currently has four state of the art, fully functional ISO12025 accredited laboratories across the UK. They are situated in Liverpool, London and two in Northern Ireland, Hollywood and Randox Science Park in Antrim. RCLS looks to expand their team of experienced scientists, working towards further accreditations and furthermore setting up two additional labs in Dubai and Los Angeles. The addition of these purpose built labs will give RCLS the ability to increase output to both the health and research market.

Ann-Marie Jennings, Laboratory Manager for Randox Clinical Laboratory Services, discusses the Randox Biochip Array, RCLS’ abilities and confidence in testing;

“On our patented Randox Biochip Array Technology we can customize bespoke testing platforms based on the requirements of each drug development project, which can be a challenging process. From initial product development to clinical trial stages there can be a number of barriers and time constraints before drugs are successfully released to the public.  We’re confident that our newly enhanced capabilities will benefit patients suffering from conditions in most need of research by offering pharmaceutical companies at the forefront of pioneering research, with the latest technological developments.”

Thanks to these state of art laboratories, RCLS will now be able to provide an increasingly wide range of testing services to Biotechnology, research and pharmaceutical companies delivering the testing services required to support their research and drug development projects.

With the ability to conduct an unrivalled range of health testing – haematology, biochemistry and immunoassay – all under one roof, the laboratory offers unparalleled support services to the dynamic and growing healthcare industry.  With a greater understanding of human complexity, pharmaceutical companies are now focusing on developing safer drugs tailored to specific patient groups or sub-groups and the expansion plans in motion at RCLS will help these organisations bring new drugs to market faster.

If you would like more information on Randox Clinical Laboratory Services, please contact us by emailing us at info@rcls.com

 


We Are Randox | Omagh Speed Networking promotes careers in STEM

We’re sure you’ve heard of “Speed Dating”, but what about “Speed Networking”? Randox’s R&D Scientist, Dr. Dwaine Vance tried it out to spread the word about Randox Careers in STEM!

Dr Dwaine Vance visited Omagh High School to represent Randox Careers. He sat down with us, and we discussed the importance of the event. Dr. Vance told us:

On Wednesday the 15th June I represented Randox Careers at a ‘speed networking’ event at Omagh High School. This involved groups of students moving from one employer stand to the next for a 5 minute ‘mini network’. There was two sessions during the morning involving GCSE level pupils. The aim of the ‘speed networking’ event was to provide pupils with opportunities to meet local Northern Irish companies within the Science, Technology, Engineering and Mathematics (STEM) sectors, of which Randox Laboratories play a pivotal role.

We, at Randox, want to inspire students to think about their own career plans and to allow them to gather information about the local job market. By doing this, we’re also giving them the opportunity to be aware of the jobs that are available and the importance of STEM related subjects,  as well as letting them see how employers value their other curriculum subjects and their personal skills and attributes.   My objective as a employee of Randox was to showcase a range of careers for all abilities within the company with a focus on STEM careers e.g. science and engineering.

The importance of spreading awareness of the opportunities in science and engineering from a young age is imperative, as many students are unaware of the vast range of differentiation in different careerpaths, stemming from one subject or degree class. Dr. Dwaine Vance went on to discuss the events of the networking conference:

As part of each ‘mini network’ I provided students with a brief overview of Randox. Students were given the opportunity to watch videos depicting our expertise and to ask questions about how their interests could be incorporated within Randox. The training department at Randox provided me with pop-up stands, recruitment pathway brochures, merchandise e.g. pens, stopwatches, mug coasters and even Biochip Array Technology key rings!

Overall the students gained a good knowledge of Randox, they were particularly keen to learn about the local and global opportunities available at Randox. In addition, students were keen to know more about the veterinary aspect of Randox. It was comforting to discover that the majority of pupils had previous knowledge of the Randox brand from the press (as we have recently experienced a great boost in brand visibility through Grand national sponsorship), Randox health (television adverts) and Confidante (local radio stations).

The pupils at Omagh High School were keen to ask me about my role within the company and what my day to day roles and responsibilities are. I was happy to provide students with my research and development activities and they were interested to hear that I was involved in the development of a genetic test that aims to predict your future risk of heart disease by investigating your own DNA.

At Randox I am part of a small team of experienced research scientists that are developing a genetic risk prediction test for heart disease and myocardial infarction. This test aims to simultaneously genotype 20 genetics variants that have been previously associated with increased risk of heart disease. This Randox molecular test is in collaboration with leading University academics and will help reduce the burden of heart disease throughout the world by providing an accurate risk assessment of disease so personalised treatment can be provided to those who require it most. To quote Randox Health, “Prevention is better than cure”.

From everyone at the Randox Careers team and from Dr. Dwaine Vance, we’d like to thank Omagh High School for inviting us to attend this incredibly beneficial Speed Networking event, where we feel we have truly impacted the young minds of tomorrow. We look forward to the future of diagnostics, with you!

Dr Dwaine Vance at Omagh High School to promote Careers in STEM
Dr Dwaine Vance, pictured with Mrs. Paula Burns, teacher and Head of Careers at Omagh High School at STEM event

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