CK-NAC Reagent

Key Benefits of the Randox CK-NAC reagent

Exceptional correlation with standard methods

The Randox methodology was compared against other commercially available methods and the Randox CK-NAC assay showed a correlation coefficient of r=0.99

Wide measuring range

The Randox CK-NAC reagent can comfortably detect levels outside of the healthy range measuring between 9.16 – 2886 U/l.

Excellent stability

Stable until expiry date when stored at +2 to +8°C

Other features of the Randox CK-NAC reagent

  • UV DGKC method
  • Available as liquid and lyophilised reagents
  • Stable until expiry date when stored at +2 to +8°C
  • Measuring range 9.16 – 2886 U/l
Cat NoSizeAnalyserEasy Read
Easy Fit
(L) Indicates liquid option
CK11020 x 2.5mlGeneral Use--
CK33520 x 3mlGeneral Use--
CK52210 x 10mlGeneral Use--
CK3812R1 4 x 20ml
R2 4 x 6ml
RX Daytona/Imola
Hitachi 717/911/912/704/902

CK7947R1 6 x 20ml
R2 3 x 10ml
Hitachi 717/911/912/704/902
RX Daytona/Imola

CK80257 x 15mlRX Suzuka
Abbott Architect
Hitachi 917/Mod P
Konelab 20i/30i/60i
Beckman Coulter AU Series

CK3892R1 4 x 16.5ml (L)
R2 4 x 6.2ml (IFCC)
RX Daytona/Imola
Hitachi 717/911/912/704/902

CK8313R1 4 x 20ml (L)
R2 4 x 7ml
RX Daytona +/Monaco
Abbott Architect
Hitachi 917/Mod P
Konelab 20i/30i/60i
Beckman Coulter AU Series

CK38786 x 20ml (IFCC) (L)RX Daytona/Imola
Hitachi 717/911/912/704/902

CK8144R1 4 x 20ml (L)
R2 4 x 8ml
RX Modena--

Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers.  Contact us to enquire about your specific analyser.

What is the CK-NAC assay used for?

What is CK-NAC?

The small amount of Creatine Kinase (CK) present in the blood primarily comes from skeletal muscle. CK is also found in striated muscle, brain and heart tissues. The CK concentration levels in the blood increase as a result of damage to bodily muscle or interferences with the muscle energy production such as myositis, which is inflammation of the muscles.

What is the CK-NAC assay used for?

The Randox CK-NAC reagent is used for the measurement of CK in serum or plasma to assess the extent of muscle damage and to monitor treatment.

The determination of CK-NAC activity in plasma or serum provides a sensitive marker for the detection of skeletal muscle disease; and is also useful to assess the extent of severe muscle trauma, crush injuries, burns or electrocution, and the likelihood of developing rhabdomyolysis.   For more information on the spectrum of rhabdomyolysis, please click here [external link].

The determination of CK using creatine phosphate and adenosine‑5’‑diphosphate (ADP) as substrates rather than creatine and adenosine‑5’‑triphosphate (ATP) has several advantages in test performance as it allows for a faster reaction rate resulting in greater sensitivity. Small sample volumes are used and sample blanks are not required.

The UV method used is an optimised standard method according to the recommendations of the Deutsche Gesellschaft für Klinische Chemie.

  • McNeill, A.J. Thrombolytic therapy within one hour of the onset of acute myocardial infarction. Q. J. Med. 1991, 79: 487-494
  • Huang, Z-Q., et al. Effects of N-n-butyl haloperidol iodide on rat myocardial ischemia and reperfusion injury and L-type calcium current. Acta Pharmacol. Sin 2003, 24(8): 757-763
  • Mohiti, J., et al. The significance of troponin T and CK-MB release in coronary artery bypass surgery. Indian J. Clin. Biochem.2004, 19(1): 113-117
  • Lu, H-K., et al. Preventive effects of Spirulina platensis on skeletal muscle damage under exercise-induced oxidative stress.Eur. J. Appl. Physiol. 2006, 98: 220-226
  • Randazzo-Moura, P., et al. A Study of the Myotoxicity of Bothropstoxin-I Using Manganese in Mouse Phrenic Nerve-Diaphragm and Extensor digitorium longus Preparations. Braz. J. Morphol. Sci. 2006, 23 (2): 237-246
  • Akpanabiatu, M.I., et al. Effects of interaction of vitamin A and Rauwolfia vomitoria root bark extract on marker enzymes of cardiac diseases. Indian Journal of Clinical Biochemistry. 2009, 24(3): 241-244

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