Westgard’s Great Global QC Survey 2017
In a QC survey conducted this year, Sten Westgard reached out to more than 45,000 laboratory professionals to gain a comprehensive view of the world’s Quality Control practices. It was one of the largest surveys that have been conducted and shared publicly.
Read on as we take a summarised look at our favourite bits.
Setting control Limits
Most labs are using their actual performance to set their mean and SD, however, a large percentage of labs still use manufacturer’s ranges, peer group ranges, and other non-individual sources for SD. These ranges can typically be set wider than they would if the ranges were based on their actual mean and SD. This can result in labs releasing incorrect patient results.
Laboratories were asked if they used 2 SD control limits on all tests and it was found that a majority use 2 SD. The strict use of 2 SD can generate a high level of false rejections (9% for two controls and higher for three). This causes a high level of out-of-control events; the use of QC multi-rules is recommended.
The types of Controls used by labs
More than 60% of labs were found to be using manufacturer controls, the drawbacks of which are well known. The latest ISO standards strongly encourage the use of independent / third-party controls. Westgard speculates that this will become a mandatory requirement in the next version of ISO 15189.
Frequency of QC
The first question about frequency asked how often labs ran QC during a run. Respondents reported how often they schedule QC in their labs. Around half only run QC at the beginning of a run with labs running it throughout the day coming in close second. A small proportion of labs reported running QC at both the beginning and the end of a run.
The final, least popular option involves spacing out QC based on test volume, the most scientific method determining how many patient samples can be run between controls without raising the risk of unacceptable results.
The next question asked about the overall frequency of QC. Most labs are meeting the once-a-day minimum standard for CLIA regulations.
“QC frequency remains primarily based on the rotational speed of the earth, not driven by needs of the clinician and patient.” – Sten Westgard
QC Frequency Influences
Regulator and accreditation requirements lead the way in influencing the frequency of QC with manufacturer recommendations, and professional judgement following close behind. Only a quarter of labs use the volume of testing to guide their QC frequency and one in six look to EP23 or IQCP for guidance.
Most labs are using on-board instrument informatics to support their QC charting, followed by LIS charting programs, and peer group software.
Of significance is the number of labs using Excel spreadsheets as their primary QC tool as well as standalone QC programs or even manual graph paper. This could be due to varying technological capabilities where some locations may not have access to, or the funds to afford, informatics.
A combined third of labs are out-of-control every day. In some labs this could be the result of running such a high volume of controls that false rejections are inevitable. However, rationalising in this way can lead to ‘alert fatigue’, where users begin to ignore alert flags and stop troubleshooting.
More than a quarter of labs have an out-of-control flag every few days while another roughly one in six have just one per week. A small number of labs report having few QC flags.
Managing QC Costs
Finally, laboratories were asked about the steps they take to manage QC costs. 60% claimed that they take no steps to manage costs. One in six reduced QC frequency, one in eight switched to cheaper controls, while, worryingly, almost one in ten changed their QC rules or widened limits.
Westgard’s Global QC Survey suggests there exists many inefficient implementations of Quality Control, with plenty of room for improvement. The current state of QC is, like many aspects of healthcare, unsustainable. Labs must adopt better approaches or risk their continuing feasibility, or worse, their patient’s results.
How Randox Can Help
Westgard highlights particular issues with labs mismanaging costs, still using manufacturer controls, and setting control limits – this is where Randox comes in.
Acusera Third Party Controls offer the highest quality solution for any lab – regardless of size or budget. Designed to provide an unbiased, independent assessment of performance, our internal quality controls have not been manufactured in line with, or optimised for use with any particular reagent, method or instrument helping you to easily meet ISO 15189 recommendations. Unrivaled consolidation allows for significant cost savings.
Acusera 24•7 Live Online allows you to automatically apply multi-rules and generate charts to help with setting accurate control limits, helping you get your quality control under control.
Reference: Westgard, S (2017), The 2017 Great Global QC Survey Results
World Diabetes Day
With World Diabetes Day on Tuesday 14th November 2017, we take a look at what diabetes is and why quality control is so important.
What is Diabetes?
Diabetes is a life-long condition which occurs when the glucose level in the blood is too high because it can’t enter the body’s cells to be used as fuel. There are two types of diabetes: type 1 and type 2. They are distinct conditions and must be treated and managed differently.
Type 1 Diabetes
Type one diabetes is an autoimmune condition in which the body attacks insulin-producing cells, this causes a lack of insulin, leading to an increased blood glucose level. Around 10% of people with diabetes has type 1.
Type 2 Diabetes
A mixture of genetic and environmental factors causes type 2 diabetes. The body doesn’t make enough insulin or the insulin it does create does not work correctly, leading to a glucose build up in the blood. It’s thought that up to 58% of type 2 diabetes can be prevented or delayed through healthy lifestyle choices.
Role of Quality Control
Quality control plays a crucial role in ensuring accurate and reliable diabetes monitoring. 70% of medical decisions are based on a laboratory test result and QC is vital in ensuring the results the laboratory report are both accurate and reliable.
Want to know what makes a good HbA1c control? Read on to find out.
Clinically Relevant Levels
In the diagnosis of diabetes, glycated haemoglobin (HbA1c) in blood provides an indication of average blood glucose levels in the previous three months. HbA1c is the recommended standard of care for type 2 diabetes monitoring. HbA1c is measured using the range below:
HbA1c – Clinically Relevant Levels
|Normal||Below 42 mmol/mol||Below 6.0%|
|Prediabetes||42 to 47 mmol/mol||6.0% to 6.4%|
|Diabetes||48 mmol/mol or over||6.5% or over|
It is important to assess the full clinical range of an assay, i.e. the range between the lowest and highest results which can be reliably reported. 48 mmol/mol is the cut-off for diabetes diagnosis, it is crucial that this can be measured accurately because any inaccuracy could mean the difference between being diagnosed and treated and not.
In terms of accreditation, ISO 15189:2012 states, ‘The laboratory should choose concentrations of control materials wherever possible, especially at or near clinical decision values, which ensure the validity of decisions made’.
Benefits of Third Party Controls
The importance of third party controls is evident. Third party controls can help identify instrument, reagent, and procedural errors. Unchecked these errors could lead to incorrect patient results, further leading to misdiagnosis.
Third party quality control material has not been designed or optimised for use with any instrument, kit, or method. This complete independence enables the quality control material to closely mirror the performance of patient samples, and in doing so, provide an unbiased, independent assessment of analytical performance across multiple platforms.
Again, in terms of accreditation, ISO 15189 states – “use of independent third party control material should be considered, either instead of, or in addition to, any control materials supplied by the reagent or instrument manufacturer.”
Many laboratories perform HbA1c testing on a dedicated machine and as a result, are not always using a third party control.
Wastage is a common issue when running HbA1c due to the pre-treatment step required for many HbA1c controls and poor stability of some controls on the market. Look out for controls with an extended open vial stability to help reduce waste and keep costs low.
How can Randox help?
To help you get your QC in check for World Diabetes Day, Randox Acusera HbA1c control contains both HbA1c and Total Haemoglobin, with a reconstituted stability of 4 weeks to reduce waste and reduce costs. To find out more about our HbA1c control visit the page using the button below or fill out the form above.
This week marks Urology Week, an important week in the annual health calendar. Urology Week is an initiative of the European Association of Urology (EAU) that aims to raise awareness of urological conditions among the general public and provide knowledge into how vital urology is to your standard of life.
What is Urology?
Urology is a surgical speciality which involves the diagnosis and treatment of disorders of the kidneys, ureters, bladder, prostate and male reproductive organs. It is an extremely varied branch of medicine and caters for patients of both genders and all ages, from infants to elderly pensioners. (1)
Did you know?
There are 25 million or 16% of Europeans above 40 years of age who experience some symptoms of urinary incontinence, with costs of this condition totalling approximately €7 billion in just 6 countries? Currently, 10% of all medical care involves Urology which is a large proportion of the annual healthcare spend. (2)
The RX series Clinical Chemistry Analysers offer a comprehensive renal testing panel which allows for a quick and accurate diagnosis to combat urological diseases.
The RX series Renal Function Test Panel is aimed to help diagnose and manage conditions affecting kidney function; these tests may be used as part of general health screening or to screen someone who is at risk of developing kidney disease.
Why choose the RX series analysers to test Renal Function?
- Extremely low patient sample volumes are required ensuring the upmost in patient comfort
- Accurate testing ensures patients can receive correct treatment as early as possible
- STAT functionality allows for the addition of emergency samples when required
- Advanced QC capabilities insuring your results are both accurate and reliable.
Follow us on Social Media
(1) The British Association of Urological Surgeons Limited. (2017). What Is Urology? Available: https://www.baus.org.uk/patients/information/default.aspx. Last accessed 26th Sept 2017.
(2) European Association of Urology. (2017). Urology Statistics.Available: http://www.urologyweek.org/what_is_urology/statistics/. Last accessed 26th Sept 2017.
This week the RX series team celebrate Diabetes Awareness Week. This is an annual event in the UK calendar, giving public the chance to raise as much awareness as possible for the condition and get involved with taking preventative action.
Diabetes is a chronic disease which causes a person’s blood sugar level to become too high. Since 1996, the number of people diagnosed with diabetes in the UK has risen from 1.4 million to 3.5 million. Of these, about 270,000 have type 2 diabetes and around 300,000 have type 1 diabetes. ₁
Diabetes prevalence in the UK is likely to rise to 5 million by 2025, therefore if we know our risks and are aware of symptoms, we can do something about this staggering figure. Certain risks associated with diabetes include age, family history, high blood pressure and being overweight. As this disease continues to challenge healthcare today it is important we take action on Diabetes Awareness Week.
Signs and symptoms of diabetes include unexplained weight loss, frequent urination, tiredness and lack of energy, excessive thirst, blurred vision, tingling sensation/numbness in the hands or feet and slow-healing wounds.
Whilst the condition cannot be cured, it is treatable and can be managed and controlled with different treatments to suit different people. There are several assays that Randox have developed to monitor and diagnose diabetes. These include; Fructosamine, Glucose and HbA1c. Monitoring diabetes is hugely important to ensure that you are safe from complications.
The RX series includes a vast Diabetes test Panel.
#DiabetesAwarenessWeek has allowed us to focus on how we can take action by diagnosing and monitoring diabetes effectively. See below three tests run on the RX series for monitoring and diagnosing diabetes.
High levels of glucose present in the blood over a sustained period of time can end up damaging the blood vessels. Glucose comes from carbohydrate foods and it is the main source of energy used by the body. Insulin is a hormone that helps your body’s cells use the glucose and helps ensure levels don’t rise too high.
HbA1c is a very common test used indicating the blood glucose levels for the previous two to three months. HbA1c levels are directly correlated with increased risk of diabetes related deaths, making HbA1c tests vital.
Fructosamine testing enables an accurate review of a person’s average blood glucose level, and therefore diabetic status over a period of 2-3 weeks. Fructosamine testing is required for medication changes, gestational diabetes, red blood cell concerns and comorbidities.
If you would like to educate yourself more on Diabetes, including the diagnosis and monitoring, complications monitoring and associated biomarkers visit our website. We also have a full test menu available here.
Check out www.diabetes.org.uk for ways in which you can be a part of Diabetes Awareness Week this 2017!
Don’t forget to keep posted on our social media accounts for more educational information all week, remember use the hashtags to join in! #KnowDiabetes #DiabetesWeek #FightDiabetes
Introducing Amy Fekkes, graphic designer of the new RX series logo.
The RX series have just launched their brand new logo! We did a quick Q&A session with the creator of the new logo, graphic designer Amy Fekkes, who works in the RX series marketing team. We asked Amy a few questions about the history of the RX brand and the process she went through to create a selection of preferred designs, through to senior management approving their favourite logo for the company to implement across the board.
How old is the RX series brand?
15 years old, the first analyser having been released in 2002. We now have 5 analysers in our range.
How many versions of the RX series logo have been created?
This is the third version.
What is the meaning behind each of the individual names of the analysers? (RX misano, RX monaco, RX daytona+, RX imola, RX modena)
Each of the analysers are named after famous racetracks around the world. This helps reinforce the idea of workflow and speedy turnaround of results.
What inspired this current brand re-fresh?
I felt passionate about the RX series and felt the old logo was not communicating the correct brand image us as a marketing team wanted to portray. Therefore, I set out to design a logo which voiced the cutting edge and innovative technology the RX series has to offer.
The new logo needed to portray a more modern brand image which would be attractive and eye-catching in order to entice new customers and build upon existing business.
What is the meaning behind the design of the new logo?
The shape of the logo is inspired by the seamless, dynamic workflow of a Randox laboratory. This modern innovative logo speaks quality and reliability with its flowing design and robust RX typeface.
The simple, clean cut, iconic design is instantly recognisable and gives us a superior edge over our competitors.
The logo helps reflect the brand image of innovative technology at the heart of the laboratory.
Why did you change the colours of the logo and what is the reason behind the new chosen colours?
I wanted to strengthen the relationship between the RX series and Randox brands. The green now correlates with the green in the Randox brand, therefore strengthening overall brand awareness.
The subtle introduction of black in the palette creates a strong clean contrast against the Randox green and communicates power and clarity.
How did you decide on the final logo?
After much in-depth research and sketching, the design was then created digitally using Illustrator®.
The final decision was a two-step process. I selected my preferred designs and presented these to the marketing team who voted on their two favourite designs. These two designs were then brought forward to senior management to make the final decision. I was absolutely delighted that my favourite of the two was chosen.
As a team, we believe that the new logo will be instantly recognisable to customers worldwide and synonymous with high quality, reliable clinical chemistry testing. Initial feedback has been very encouraging and we look forward to strengthening our presence globally through our modern, innovative logo.
Make sure to check out our social media accounts for more!
From April 23rd to April 29th we are celebrating Medical Laboratory Professionals Week! This is a week dedicated to raising awareness for those who work in a laboratory & the hard work that goes unnoticed every day in laboratories around the world.
Have you ever wondered what happens between submitting your patient sample and receiving your results? Have you ever wondered who conducts the detailed laboratory testing for your annual check-up such as cholesterol and glucose levels? Or who analyses these results? The answer, a Medical Laboratory Professional (MLP). MLP’s provide up to 70% of the medical laboratory results for physicians and others to make informed decisions about a patient’s diagnosis and aftercare treatment plan. The work that laboratory professionals do each and every day is integral to providing excellent patient care. They perform and interpret billions of laboratory tests every year.
Providing accurate and reliable test results is of the utmost importance for laboratory professionals and also for us at Randox. With a passion for Quality Control, and with more than 30 years’ experience developing Laboratory QC for the in vitro diagnostics market, we believe in producing high quality material designed to streamline procedures, whilst reducing costs in laboratories of all sizes and budgets. These qualities have been reflected in our Acusera true third party quality controls, Acusera 24.7 interlaboratory data management software, Acusera Verify Calibration Verification material and RIQAS, the largest international EQA scheme.
Randox Quality Control would like to take this opportunity to thank all the laboratory professionals around the world and especially our own laboratory staff – you truly are the “Unsung Heroes of Healthcare”.
Medical Laboratory Professionals Week is taking place this year from 24th-30th April 2017. This is an annual celebration of professionals working in the laboratory, highlighting and recognising their contributions to medicine and healthcare.
To celebrate Medical Laboratory Professionals Week the RX series interviewed Emmett Donnelly, one of our R&D Scientists at Randox to find out more about what his job in the lab entails day-to-day. Emmett works with the RX series of clinical chemistry analysers and Randox reagents on a daily basis to develop or improve new tests for the market.
We asked Emmett a few questions about his life as a scientist. See what he gets up to in Randox on a daily basis …
What attracted you to a career in laboratory science?
I have always been interested in science and around the time of GCSEs I had a fantastic science teacher that made the subject interesting and easy, so from there I wanted to follow some kind of Science related career. When I learned about the role of Biology and Chemistry in pharmaceuticals and diagnostics I wanted to become more involved in that area.
What were you good at in school?
I was always interested in science so did well in these subjects. I also did well in maths and loved technology class. I took sciences to A’ level and liked languages so took French at A level too. I was never really that interested in history or arts so these were never my strong points come exam times.
What do you do in your job for Randox?
I am primarily involved in the Development and improvement of new reagents making sure that they work to a high standard on our automated analysers. I am also involved in troubleshooting product and customer queries, transfer work onto new analysers and some formulation of products.
Can you tell us an example of your daily routine as an R&D scientist?
I’m usually involved in a project so I work through all the data that needs to be generated for that. However product and customer queries may come through the lab and this would take priority. Other studies such as stress studies and stability may need done at the same time every week and is therefore scheduled. I am dealing with emails, calls throughout the day and more recently mentoring of graduate and placement students.
What is your favourite test to perform & why?
I like several tests. I like simple tests such as ALP, AST and Creatinine designed to monitor the health of our vital organs. I also like tests such as IGs designed to test for infection and Therapeutic Drug tests like Valproic acid and Theophylline used to monitor patient response to therapies.
What aspects of your job do you enjoy the most?
I generally like being involved in an area that improves people’s wellbeing. It’s nice to develop a new product and get it performing to a point that can be used in the market especially if it is something that has never been produced before.
What are some common preconceived ideas the public have about what laboratory staff do?
I think the public have little knowledge of what happens in a lab. They have an interest but tend not to question in detail what staff do because they perhaps think that the work is too complex for them to understand. I also think that the public isn’t aware that practically everything they use in daily life has been developed in a laboratory environment and fail to see the link between primary testing and the final product.
In your opinion, what are the most important aspects of laboratory work?
It is important that all work is carried out in accordance to Standard Operating Procedures to keep in line with Regulatory criteria. It is also important that the analyst knows their exact aims and have the right technical knowledge to achieve these aims. It is especially important to keep with deadlines as well if the Laboratory work is business based.
What are common errors of pipetting?
FinnPipettes require routine maintenance so it’s important that they are calibrated and maintained properly. When using them it’s important that liquid is removed and dispensed slowly to avoid air bubbles. Too fast and air will be introduced into the plastic tip resulting in inaccurate volumes. It’s also important that with viscous liquids not to forget to remove excess liquid from the tip. Users also sometimes place pipettes on the bench horizontally with the tip on resulting in material finding its way into the pipette. Slow adjustment of the volume control will prolong the life of the pipette. With normal pipetting it’s important to always read the liquid meniscus at the required reading.
What’s in your lab coat pocket?
I have a calculator, a couple of pens and a marker though I have a habit of losing mine so they probably belong to my work mates.
In what ways does your work make a difference to people’s lives?
For me my work supports the old saying Prevention is better than cure. The use of Diagnostic reagents help detect the development of disease at an early stage and therefore enable something to be done about it early. In addition, the reagents can be used to monitor treatment during illness as the results will tell if treatment is working.
Emmett is a fundamental member of the Randox team and plays an essential role in the diagnosis and prevention of disease through research and development of new tests. Without our valuable laboratory team working extremely hard behind the scenes the lifesaving work we do here at Randox would not be possible.
To find out more about Randox products contact us at theRXseries@randox.com.
Check out our social media sites for more on Medical Laboratory Professionals Week.
With a major focus in R&D, Randox scientists work in pioneering research into a range of common illnesses such as cancer, cardiovascular disease and Alzheimer’s disease. Over 16% of turnover is reinvested in R&D, and therefore, we have more new tests in development than any other diagnostic company.
Of our 1400-strong workforce, almost 400 are research scientists and engineers. Over the past year alone these highly-skilled specialists have developed a new test for Alzheimer’s disease, a bladder cancer test and a test with the ability to stratify Acute Myeloid Leukemia (AML) patients, to determine patient response before chemotherapeutic treatment.
We were also the first company in the world to bring to market a test to detect ‘Flakka’, a dangerous and highly addictive new psychoactive substance.
Most recently we announced the official opening of our new research and testing laboratory, Randox Clinical Laboratory Services (RCLS), at the Randox Science Park in Antrim, Northern Ireland.
Research areas at the newly accredited laboratory include but are not exclusive to cancer, fertility, heart, inflammation, stroke and kidney health, both in-house and collaboratively with external organisations.
Current and past collaborations include an Acute Kidney Injury Study with the Royal Victoria Hospital, a Bladder Cancer Study in partnership with Queen’s University Belfast and The Belfast Trust, a Stroke and Brain Injury study with Cambridge University, and key partnerships with a number of major pharmaceutical companies.
Our R&D projects are known across the world for their ingenuity and relevance to current health issues.
Both our Bladder Cancer project and our Acute Myeloid Leukemia projects were awarded Innovate UK Research Awards, which enabled economic studies to be carried out by The National Institute for Health Research Diagnostic Evidence Co-Operative. These DECs will investigate the economic benefits of the new diagnostic tests for The National Health Service, and their role in the current patient care pathway.
Our revolutionary Alzheimer’s disease test was presented with a NACB / AACC Distinguished Abstract Award at the American Association for Clinical Chemistry Annual Scientific Meeting and Clinical Lab Expo, in Philadelphia.
We have also recently established a collaborative agreement with Dr. Carl Novina at the Dana-Farber Cancer Institute and Harvard Medical School. The goal of this collaboration is to develop therapeutic antibodies that will be incorporated into a platform technology that can reprogram patients’ immune systems to attack cancers.
Our research and development programme at Randox is continuously evolving to address the most pressing health issues. We are committed to improving health worldwide and as such will continue to focus our R&D efforts where they are most needed.
Please see below for some examples of our latest research and development news stories.
QC Material Stability
Stability has a number of different definitions, however, the most relevant to clinical diagnostics, and indeed quality control sera, is the “resistance to chemical change or physical disintegration”. Much like a chain, your quality control system is only as strong as its weakest link, or in this case analyte.
Whilst we appear to be stating the obvious here, this might not be as straightforward as it first appears. The product literature you peruse will help you decide what control best suits your needs, whilst many companies will state their control stability in the literature there are some instances where all may not be as it first appears. It is also important to note that some manufacturers may not make stability claims for some of the analytes listed in their control material. In such instances, you are required to validate these in-house, taking up precious time and resources.
Dig a Little Deeper
Whilst we understand that some analytes do have limitations due to their inherent nature, misleading analyte claims can cost the laboratory both time and money. In a recent survey conducted by Randox, 65.5% of respondents indicated that they felt stability was a ‘Very Important’ QC feature. As such it’s important that you look beyond the sales literature when it comes to control stability. Look out for exceptions in the small print of the control kit inserts. For example, if a control has a stability claim of 7 days at 2-8oC and a routine analyte like Cholesterol has a stability claim of just 2 days at 2-8oC then the true stability of the control is only 2 days. In such instances, there is a lot of potential for waste, as laboratories will be required to prepare a new vial of QC material every 2 days leading to increased costs and time. However, if you dig a little deeper into the controls and always read the small print, you could avoid such issues.
How can Randox Acusera benefit you?
For more than 30 years Randox has been shaping the future of clinical diagnostics with our pioneering high quality, cost effective laboratory solutions. Quality Control is our passion, we believe in producing high-quality material that can help streamline procedures, whilst saving money for laboratories of all sizes and budgets. We pride ourselves in not misleading our customers with false stability claims for our controls. With controls such as our Liquid Cardiac and Specific Proteins Controls, you could benefit from a 30-day open vial stability for all analytes, without exception.
By employing our Randox Acusera quality control materials you could benefit from;
Commutable controls, ensuring a matrix that reacts to the test system in the same manner as a patient sample, enabling an accurate and reliable assessment of instrument performance.
Accurate target values that won’t shift throughout the shelf life of the controls, eliminating the need to spend valuable time and money assigning values in-house.
Consolidation of test menu with controls comprising up to 100 analytes, reducing preparation time and storage space required.
Analytes present at clinically relevant levels ensuring accurate test system performance across the clinical range, maximising laboratory efficiency by eliminating the need to purchase additional high or low-level controls at extra expense.
True third party controls designed to provide an unbiased assessment of performance, our Acusera controls have not been manufactured in line with or optimised for use with any particular reagent, method or instrument.
For more information on any of our products, or to request a consultation from one of our QC Consultants, contact us via firstname.lastname@example.org.
Randox celebrates British Science Week 2017
Last week was British Science Week 2017, an annual campaign that aims to inspire innovation and celebrate science. To mark the occasion, Randox Laboratories got involved by celebrating the innovation of each Randox product group. The product groups within Randox shared a series of posts, videos and blogs showcasing the #ScienceBehindRandox throughout British Science Week.
To initiate the Randox British Science Week campaign, Randox shared this video, which highlights the company’s dedication to improving health worldwide. The video provides an introduction about each product group, however throughout British Science Week, each product group has gone into further detail about the #ScienceBehindRandox.
Randox Careers, the RX series, Randox Reagents, Randox Quality Control, Randox Toxicology, Randox Biosciences, Randox Testing Services, & Randox Food Diagnostics all got involved in the British Science Week Campaign. You can read a snippet of each product groups post below, with videos and links to the full content also provided. We hope you enjoy learning about the #ScienceBehindRandox.
Randox – Dedicated to improving health wordwide.
Joanne Darragh spent some time with Randox Careers to discuss her role as R&D Toxicology Manager.
“Working in this area has been both challenging and exciting as we are at the cutting edge of assay development. We work in a great team and we work along very closely alongside other departments such as Marketing & Sales so that we are in close contact with what the customer needs, which means we are producing relevant tests very quickly and effectively. Every day brings a new challenge.”
– Joanne Darragh, R&D Toxicology Manager
Listen to what Joanne had to say on the video above
Randox RX series
As part of British Science Week, the RX series caught up with Daniel Melly, one of our very talented Mechanical Design Engineers based in Randox Teoranta in Dungloe, Ireland.
Daniel was an integral part of the team involved in the design of our new semi-automated analyser, the RX misano. The RX series asked Daniel a few questions about why Randox created this analyser, the design process involved in creating such a unique system, and what his favourite features are.
“Randox set out in creating the RX misano with the philosophy of supplying the customer with a more modern, reliable, and aesthetically pleasing analyser than those that are currently available on the market. Robust part selection was always at the fore of any design decisions, and we feel that we have delivered on all of these requirements.”
– Daniel Melly, Randox Mechanical Design Engineer
One unique test by Randox, adiponectin, is becoming an increasingly significant biomarker for health professionals. Low levels have been linked with several illnesses including metabolic syndrome, cancer and cardiovascular disease.
What is adiponectin?
Adiponectin is a protein hormone produced and secreted by fat cells called adipose tissue. Adiponectin is normally found in relatively high concentrations in healthy individuals. Its role in the body is to regulate the metabolism of lipids and glucose, which influences the body’s response to insulin and inflammation.
At Randox, our R&D Scientists are helping to change healthcare. By investing heavily into research and development to develop unique diagnostics tests, such as the adiponectin test, Randox provide doctors with the ability to identify disease risk sooner- offering the opportunity to prevent illness, rather than the need to find a cure.
Randox Quality Control
One Simple Change to Randox Quality Control can save your laboratory time and money.
Randox Quality Control are a world leading manufacturer of true third party controls with over 390 analytes covering Antioxidants, Blood Gas, Cardiac Markers, Routine Chemistry, Coagulation, Haematology, Diabetes, Immunoassay, Immunology, Lipids, POCT, Therapeutic Drugs, Toxicology and Urine Chemistry, providing complete test menu consolidation. Randox Quality Control produces the most consistent material available with the most accurate target values.
Randox Quality Control guarantee to simplify QC practice in any laboratory, just ask one of their 60,000 users worldwide.
Find out more information about Randox Quality Control in the video above
Randox Toxicology provides trusted solutions for the screening for drugs of abuse. With significant reinvestment in Research and Development, we persistently stay ahead of this ever challenging market. Being the first to develop New Psychoactive Substances tests such as fentanyl, bath salts and flakka allows us to maintain our position as a global leader.
Our pioneering technology has created a number of advancements in the field of toxicology. In particular, our patented Biochip Array Technology which can simultaneously screen from a multi-analyte testing platform, achieving a complete immunoassay profile from the initial screening phase.
During British Science Week, we are delighted to introduce you to our latest development utilising this technology; our Gastropanel Array,* a multiplex test engineered to diagnose those at risk of developing peptic ulcers and gastric cancer using non-invasive methods.
Our Gastropanel Array encompasses two quantitative assays, a H. pylori assay for the detection of antibodies produced in response to a H. pylori infection, a common cause of gastric cancer1 as well as a 3plex Gastropanel assay, for the detection of pepsinogen I (PGI), pepsinogen II (PGII) and gastrin 17 (G17).
Currently recorded as the world’s 5th most common cancer, the majority of gastric cancer cases are diagnosed after presenting as an emergency, when treatment may be less effective due to the cancer being at an advanced stage, highlighting the need for the availability of diagnostics tests like our Gastropanel Array to enable practitioners to administer prompt treatment and ultimately increase survival rates on a global scale.
Randox Testing Services
Randox Testing Services have shown how they are at the forefront of continually reacting and developing tests for NPS. NPS (formerley known as Legal Highs) have had devastating effects on users since emerging in the UK in 2008. These substances are highly dangerous and have caused unnecessary deaths. This is due to the effects from different elements used in production. Legislation concerning the substances changed in 2016 with the implementation of the Psychoactive Substance Act.
How have Randox Testing Services implemented change? Find out in the video above
Randox Food Diagnostics
Of the 41 antibiotics that are approved for use in food-producing animals by the FDA, 31 are medically important for human health. Randox Food Diagnostics provides advanced screening solutions for 94% of these antibiotics including beta-lactams, quinolones and tetracyclines, allowing you to ensure the integrity of your end product without compromising quality. Randox Food provides multiplex screening solutions validated across a range of matrices including urine, serum, tissue, milk, honey and feed.
The Evidence Investigator matched with Biochip Array Technology (BAT) provide the end user with fast, reliable results to aid in ensuring your produce is antibiotic free. BAT provides a platform for the simultaneous determination of multiple drug residues from a single sample using miniaturised immunoassays with implications in the reduction of sample/reagent consumption and an increase in the output of test results.