Randox Food Diagnostics: Infiniplex Array for Milk
Drug residues in milk present major concern for farmers, dairy processors, cheese manufacturers, authorities and consumers due to the potential public health and industrial implications. Through the potential inappropriate antimicrobial use in animals producing product for human consumption, antibiotic-resistant organisms can enter the food supply or can spread to various components of the ecosystem. For consumer protection, regulatory limits have been set for the majority of compounds.
Randox Food Diagnostics provides screening technology to monitor the levels of these potentially harmful compounds including the Infiniplex for Milk Array available on the Evidence Investigator and Evidence Multistat analysers.
Using the Randox Food technology the user can identify 130 analytes from a 200µl sample of raw milk and follows this simple process to results:
- Pipette the sample directly onto the MultiSTAT biochip
- Insert into the Evidence MultiSTAT
- Press Play and follow the on-screen prompts
- Results appear on screen in under 20 minutes
Developed to provide an easy to use option for the user, the Infiniplex Array for Multistat can be used by anyone to ensure rapid on-site testing within the dairy industry.
The InfiniPlex test menu is 98% compliant with EU regulations and screens for additional contaminants including; antiparasitic, anti-inflammatories, non-steroidal and unauthorised substances from one sample of raw milk, creating a better end product for the processor and end user.
To find out more about InfiniPlex contact email@example.com
In the month of May alone, over 20 cases of feed and cereal based products have been rejected at EU borders after testing positive for aflatoxins with a risk decision level marking of ‘serious’, countries of origin include; Turkey, Egypt, Gambia, U.S, Indonesia, India, Azerbaijan and Spain.
The European Union have set tolerance levels for Aflatoxin B1 at 2 parts per billion (ppb) and total aflatoxins at 4ppb for nuts, cereals and dried fruits.
Aflatoxins are a mycotoxin produced by a fungus and thrive in hot and humid climates. Aflatoxin B1 is the most prevalent among food products and commonly occur among cereals (including wheat, barley, rice and corn) oilseeds (peanuts, almonds, pistachios and other nuts) spices, fruits, vegetables, milk and dairy products.
Screening for Mycotoxins
There are various screening methods available for mycotoxins in food, but few offer the choice of screening for multiple mycotoxins from one sample. Randox Food Diagnostics has created patented Biochip Array Technology (BAT), an immunoassay ELISA based method, to save the feed and cereal industry time and money on testing.
The Myco Array kit range can screen for 3-10 mycotoxins simultaneously from a single sample and depending on the users testing requirements, customisable kits are available.
For more information on mycotoxin screening with Randox Food Diagnostics contact firstname.lastname@example.org
Mycotoxins are poisonous chemical compounds produced by certain fungi. There are many such compounds, but only a few of them are regularly found in food, farmed crops and end product animal feeds. Since they are produced by fungi, mycotoxins are associated with diseased or mouldy crops. Those that do occur in food may have an impact on livestock and the health of humans and have been associated with conditions such as asthma, respiratory infections and chronic fatigue. The main causes of mycotoxins within stored grains are when the grain is damp, damaged or cracked and kept in insufficient storage conditions.
The formation of mycotoxins is climate-dependent, with temperature and moisture levels directly impacting fungal growth. Evidence shows that climate change is causing increasing temperatures and altered rainfall patterns. Additionally, extreme weather incidents have increased. As a consequence of these changes, increased levels of mycotoxins have been observed in some European crops.
Mycotoxins occur, and exert their toxic effects, in extremely small quantities in foodstuffs. Their identification and quantitative assessment therefore generally require sophisticated sampling, sample preparation, extraction, and analytical techniques. Under practical storage conditions, the aim should be to monitor for the occurrence of fungi. If fungi cannot be detected then there is unlikely to be any mycotoxin contamination. The presence of fungi indicates the potential for mycotoxin production, and the need to consider the fate of the batch of commodity affected.
In order to help the industry Randox Food Diagnostics developed the Evidence Investigator analyser. The Investigator uses Biochip Array Technology (BAT), a technology that was developed by Randox, to detect multiple residues (up to 45) from a single sample. Within farmed crops Randox Food Diagnostics provide testing for different matrices such as: Maize silage, maize, Barley, grass seed, rice, wheat, oats, soya, DDGS, rapeseed as well as livestock and pet foods including premixed feed.
Randox Food Diagnostics offer a mycotoxin screening array on Biochip called Myco 10 which can detect 10 mycotoxins per sample including aflatoxins G1/G2 & B1/B2, ergot alkaloids, fumonisins, paxilline, ochratoxin A, diacetoxyscirpenol, deoxynivalenol (DON), T2 toxin & zeralenone. Also offered is a range of ELISA test kits including ergot alkaloids.
Randox Food Diagnostics is a regular participant in the FAPAS proficiency testing scheme which provides an independent check of a laboratory’s procedures to ensure the delivery of quality results. To read our study on: Biochip Array Technology for the reliable performance of multi-mycotoxin determination in animal feed materials” click here: http://www.randoxfooddiagnostics.com/docs/default-source/randox-fd/posters/bat-mycotoxins-in-animal-feed-materials.pdf?sfvrsn=4
Mycotoxin contamination is a real and constant threat for feed and animal compound producers globally. Recently the University of Guelph, Guelph, Ontairo stated that the different geographical locations of cattle mean between 10 and 20 mycotoxins can be present at once. This is a result of extreme weather patterns across the US with excess moisture and drought in different areas causing an increase in the frequency of mycotoxins, creating challenges in protecting livestock from ingesting contaminated feed.
The most common mycotoxins found are Aflatoxin, Fusarium, Deoxynivalenol and Zearalenone. Aflatoxin is produced by Aspergillus flavus, a tropical fungus that thrives in high humidity and affects an animal’s liver, causing cancer in more extreme cases. Fusarium can develop in most temperate climates across the U.S and Canada. Fusarium poses a higher threat than other toxins as there are hundreds of different chemical structures to analyse to enable identification of the Fusarium.
Difficulties also arise in finding an analytical method sensitive enough to detect mycotoxins at low levels of contamination as small amounts can still lead to fatal results in horses, dogs and cats.
To prevent mycotoxin infection in feed, processors can implement a routine screening procedure with the help of Randox Food Diagnostics. Randox Food offer a multiplex screening system for the simultaneous detection of up to 10 of the world’s most prevalent mycotoxins including: Paxilline, Fumonisins (part of the Fusarium group), Ochratoxin A, Aflatoxin G1/G2, Aflatoxin B1/B2, Ergot Alkaloids, Diacetoxyscirpenol, Deoxynivalenol, T2 Toxin and Zearalenone. All compounds are screened at low limits of detection using Biochip Array Technology.
Biochip Array Technology is a patented technology created by Randox to facilitate the detection of contaminants and drug residues with over 20 evaluated matrices in feed (see full list below).
|Animal Feed (Complete)||Millet||Sunflower|
|Cotton Seed||Rye||Feed Pea|
|Distillers Grain||Silage||Vetches (Vica)|
Bees and other pollinators are vital to three-quarters of the world’s food crops but have been in serious decline in recent decades. The destruction of wild habitats, disease and widespread pesticide use are all important factors.
Global honey production is projected to reach 2.4 million tons by 2022 this is driven by a growth in consumers demand for a natural and healthy alternative to artificial sweeteners, a rising awareness over the benefits of using honey as a sweetener over cane sugar and the realisation of the antibacterial and inflammatory properties of manuka honey.
The decline in the numbers of bees and rising demand from consumers for natural honey products has created a market for “illegal honey” being produced to supply the demand. Producers ‘cut’ their honey with additives like high-fructose corn syrup and brand it as natural honey, affecting purity and reducing cost.
‘Honey laundering’ has also become an issue, with countries such as China using non FDA approved chemicals within beekeeping and being non-compliant to regulations causing their honey to be banned from entering the USA. To get around this, Chinese honey is being shipped into countries such as Vietnam where it is then re labelled and moved into the USA with a new country of origin on the label. This has created the need for a reliable and accurate way to test honey globally.
In order to help the industry Randox Food Diagnostics developed the Evidence Investigator analyser. The Investigator uses Biochip Array Technology (BAT), a technology that was developed by Randox, to detect multiple residues (up to 45) from a single sample. Tests for honey include a vast range of antimicrobials such as Quinolones, Streptomycin, Chloramphenicol, Nitrofurans and more. Randox Food Diagnostics are also releasing a pesticides array in early 2018. Also offered are a range of ELISA test kits.
Alongside the evidence Investigator Randox Food Diagnostics developed the RX misano for enzymatic analysis of honey. The RX misano is now available for the analysis of diastase, total sugars (glucose/fructose), HMF (hydroxymethylfurfural) & colouration, with sucrose coming in 2018.
Randox Food Diagnostics will be attending Bee Happy Expo in Bulgaria from 1st – 4th March 2018 Stop by booth 25 or catch our presentation on Saturday 3rd March at 14:30 to learn more about our product offering for honey.
For more information visit the Randox Food Diagnostics website at: http://www.randoxfood.com/matrices/honey
Or email: email@example.com
Honey naturally contains a small amount of enzymes which can vary widely by floral source and region. These enzymes play an important role by contributing to functional properties of honey, making it a unique ingredient that is far more complex than other sweeteners.
According to the EU Honey Directive 2001/110/EC, certain composition criteria must be determined for honeys intended for human consumption. In order to achieve this, the most modern enzymatic analyser in the industry, the RX misano, is now available for the analysis of diastase, total sugars (glucose/fructose), HMF and colouration.
Designed with the user in mind, the RX misano incorporates a responsive touch screen display, test menu personalisation and the ability to upload new parameters via USB. With an increase in automatic features, the RX misano also guarantees the precision and accuracy of results, improving the overall efficiency and versatility of enzymatic honey analysis.
The RX misano for honey suits a wide variety of users from bee keepers, to large honey producers/packagers and QA laboratories. It’s table top size allows it to be very versatile in different locations and needs very little maintenance from the user. The user-friendly interface and simple sample preparations means there is no need for the user to have had previous lab experience to run honey samples with the analyser.
For a summary of the benefits of the RX misano see below.
7” responsive touch screen display, favourites menu, on screen prompts, the ability to export data into excel and import new menus.
With the ability to automatically calculate results, the RX misano leaves less chance for human error.
Customisable test menus
As the RX misano for honey test menu continues to grow, users can simply upload new parameters to the machine via USB.
Results are quantitative and produced within +/- 1% of UKAS accredited reference materials, boasting increased accuracy compared to alternative methods.
Reduced foot print
With a smaller footprint than standard spectrophotometers, the RX misano is suitable for laboratories of all sizes.
Excellent thermal performance
The RX misano heats to 37°C in less than 30 seconds and cools from 37°C to 25°C in less than 1 minute.
For more information on the RX misano or any of our other honey testing options please email us at: firstname.lastname@example.org.
Pet Food companies worldwide are working towards constantly improving and maximising the quality of their product. The problematic topic of mycotoxin contamination in pet feed is quickly becoming a major cause for concern. This is due to the risk they pose for animal health and with the increasing prevalence of mycotoxins globally the focus is on pet food companies to meet EU and FDA regulations and maximise the quality of their product.
What are Mycotoxins?
Mycotoxins are naturally occurring metabolites that are produced by certain moulds and with the ability to develop and grow on a variety of crops they can affect large amounts of feed and increasingly, pet food. If a sample tests positive even for low levels of contamination the toxins are still strong enough to cause illness in animals, and if low levels are consumed over a long period of time this can result in chronic illnesses including; cancer, organ damage and neurological disorders.
The main mycotoxins of concern in pet food are;
- Deoxynivalenol (DON)
- Fumonisins (FUM)
- Zearalenone (ZEN)
- T-2 Toxin
Contamination can occur in any country around the world and at any stage of production. Herein lies the issue of how to prevent mycotoxin pollution, to tackle the issue head on and work towards a mycotoxin free product is the joint responsibility of feed producers, supply chain partners and quality control laboratories ensuring the complete safety of the product.
How can you tell if an animal has ingested pet food contaminated with mycotoxins?
In terms of animal health, mycotoxins can cause a variety of problems. Severity and symptoms can vary from animal to animal but general symptoms include; hyperactivity, vomiting, high temperature and loss of coordination. If you suspect your pet has been affected by mycotoxins you must bring them to the vet for immediate treatment.
The European Union currently regulate all the mycotoxins listed above and are subject to maximum or recommended residue limits. In the US, FDA regulations are limited to aflatoxins, DON and fumonisins, see table below for FDA regulations. If mycotoxin levels in feed fail to meet FDA standards, mass amounts of feed may need to be destroyed as grain producers are prohibited from mixing contaminated feed with clean feed to reduce the mycotoxin levels.
|Immature Animals||Aflatoxins||Corn/ peanut/ other ingredients||20 ppb|
|Adult Pets||Aflatoxins||Corn/ peanut/ cottonseed meal/ other ingredients||20 ppb|
|DON||Grain/ grain byproducts, not to exceed 40% of diet||5 ppm|
|Fumonisins||Corn/ corn byproducts, not to exceed 50% of the diet||10 ppm|
How do we tackle the problem?
Safe, reliable screening solutions for different variations of mycotoxins are available that can ensure only mycotoxin free feed is produced. Randox Food Diagnostics have created mycotoxin screening platforms as a response to increased levels of mycotoxins being found in feed globally.
The platforms use patented Biochip Array Technology (BAT) so pet food producers can test for multiple toxins from a single sample. Randox Food Diagnostics have a range of mycotoxin Biochip Arrays available with customised arrays available to suit the specific screening needs of certain producers. Each Biochip format uses a straightforward extraction process with a 50µl sample of feed, available tests include; Fumonisins, Ochratoxin A, Aflatoxin G1/G2, Aflatoxin B1, Paxiline, Ergot Alkaloids, Diacetoxyscirpenol, Deoxynivalenol, T2 Toxin and Zearalenone.
For more information on mycotoxin screening with Randox Food Diagnostics contact email@example.com
Improving global dairy standards is the focus for Randox Food Diagnostics, which is demonstrating its latest advancement – the ‘InfiniPlex for Milk’ – at the 2017 World Dairy Summit. Over 1000 international delegates are expected to attend the event being held in Belfast’s Waterfront Hall between 30th October to 3rd November.
With maintaining consumer confidence in the safety and integrity of dairy products featuring as one of the key topics at this year’s summit, the Northern Ireland-based company is keen to showcase how it can help producers get an edge in the market through ensuring food safety.
At the International Dairy Foundation’s annual conference event Randox Food will be showcasing the InfiniPlex, an innovative system which tests for 130 restricted drugs from one sample, such as antibiotics, non-steroidial anti-inflammatory and anti-parasitic drug residues. This is the most comprehensive array on the market and achieves 98% compliance with EU regulations.
The Infiniplex also identifies a number of drug compounds which are not on the EU’s regulated list but which are unsuitable for human consumption. Using this multiplex system ensures that any Randox-tested dairy product will be the safest on the shelf.
Dr FitzGerald, Founder and Managing Director of Randox Laboratories, commented;
“It is our aim to ensure that dairy producers have access to the latest and most comprehensive milk safety screening technologies. The Infiniplex for Milk is the world’s first screening technology that ensures dairy processors are compliant with regulations. By meeting its complex needs, InfiniPlex is changing the face of the global dairy industry.”
David Ferguson, Global Business Manager for Randox Food Diagnostics, added;
“Standard industry practice means the primary residues for which screening is carried out is usually limited to two certain varieties of antibiotics. The InfiniPlex for Milk provides a unique insight into the specific combination of drug compounds detected in a single sample offering drug discrimination that allows the user to see what commercially available drug was administered at animal level. Using our multiplex testing offers the global milk industry the most comprehensive product for the analysis of veterinary drug residues in food, protecting the food industry and the consumer.”
The International Dairy Federation World Dairy Summit takes place in the Waterfront Hall. Randox Food Diagnostics can be found at Booth 5.
For further information about Randox Food Diagnostics milk testing, please visit: http://www.randoxfood.com/Matrices/Milk
For any further questions please contact Randox PR by phoning 028 9445 1016 or emailing RandoxPR@randox.com
Global leader in food screening technology, Randox Food Diagnostics have developed a range of pioneering honey quality tests which are being adopted by apiculturists across the world to ensure the safety and quality of their produce.
The array of tests, developed by the Antrim-based firm, are being showcased this week at the world’s largest apiculture meeting, the Apimondia International Conference, being held in Istanbul, Turkey from September 29th to October 4th.
The company hopes to highlight to consumers and producers about the importance of food safety, and in particular the dangers of antibacterial residue in food. Scientists have warned that antibiotics used in food production, are passing through the food chain to consumers and therefore contributing to the rise in infections caused by antibiotic-resistant bacteria.
Randox Founder and Managing Director, Dr Peter FitzGerald, commented;
“As a company committed to supporting the fight against antibiotic resistance we must continue to drive awareness amongst producers and consumers alike.
“We are working closely with industry to promote a responsible approach to antibiotic use in food production and we hope that by working with some of the biggest names in the apiculture market, other honey producers will see the benefits of being able to offer their customers complete consumer confidence in a high quality, and importantly, safe product.”
At Apimondia 2017 Randox Food Diagnostics will showcase a range of major technological advancements including the firm’s Antimicrobial Array 1 Ultra, Antimicrobial Array II Plus and Antimicrobial Array V. Thanks to Randox’s patented Biochip Array Technology, these testing panels can simultaneously screen for multiple antibiotics that are sprayed on beehives to ensure the safety of the colony, from only one sample of the produce.
Randox Food’s Antimicrobial Arrays join the company’s already extensive menu of honey screening tests, including its test for Hydroxymethylfurfural (HMF), a test for an organic compound produced by dehydration of sugars, which can be indicative of overheating, poor storage conditions or aged honey. The test was recently validated by leading South American honey producer Geomiel, which credited Randox Food for delivering an immediate improvement in the quality of its honey products.
David Ferguson, Global Business Manager for Randox Food Diagnostics, commented;
“We welcome the fact that so many of the world’s leading producers, including Geomiel, have embraced our vision of continuously improving testing standards.
“We have invested a lot in simplifying the process of conducting multiple tests, and consolidating this onto one unique biochip is a cost-effective way for the honey industry to maintain and improve standards. Apimondia 2017 attendees will be offered a complete testing bundle – including our popular analysers, the Randox Evidence Investigator and RX misano, to enable them to test for antibiotics and assess quality in one easy-to-manage system.
“Another unique feature of what we offer here at Randox Food Diagnostics is our ever-expanding test menu. The RX misano for example has a customisable test menu which allows clients to upload new parameters using USB, ensuring access to the most up-to-date tests on the market.
“We will be inviting Apimondia guests to learn more about the upcoming launch of our new pesticide tests, which will provide multiple results for the world’s most prevalent pesticides, such as Amitraz, Acetamiprid, Carbofuran, Carbaryl, and Paraquar. We remain committed to supporting food producers by providing them with the newest and highest quality tests.”
For further information about Randox Food Diagnostics honey testing, please visit: http://www.randoxfood.com/Matrices/Honey
For any further questions please contact Randox PR by phoning 028 9445 1016 or emailing RandoxPR@randox.com
This week over 100 cows on a farm in New Zealand had to be put down after digesting fungus from an infected feed supply. The herd in the Southland and Otago regions was suffering from ergot toxicity. Randox Food Diagnostics have developed the only test for this fungus on the market, which can protect your animals from injury or death.
Ergot Alkaloids are a naturally occurring fungus most commonly found in grains and grasses. Produced by a group of fungi called the Claviceps species, they infect seed heads of plants during the flowering period. The fungus replaces the developing grain with toxic ergot. The dry summer and wet autumn this year provided the optimum growing conditions for the fungus.
Typically, it causes lameness and swelling of the fetlocks and hock joints but in the most severe cases animals can lose tips of their tails, or ears or even their hooves. As in this case, it can result in animals being put down.
While all animals are at risk of contracting ergot, it is most commonly found in cattle.
According to the report, VetSouth Winton veterinarian Hayden Dore confirmed four cases have been reported in Southland and South Otago with a large number of infected cows.
“Over time it effectively causes one or more of the limbs to become gangrenous. Signs of ergot toxicity generally start with a disinterest in feed, before moving to lameness in the limbs, which presented similarly to foot rot, but without the separation of the toes. Once the limbs go cold from lack of blood supply, it would take about a week before the limbs began to fall off,” he said.
“One herd with 900 milking cows had around 130 cows infected by the poisonous fungus, with subsequently 61 of them being put down.”
Testing for Ergot Alkaloids
Randox Food Diagnostics offer the only array on the market to test for Ergot Alkaloids. Validated for flour and seed, the ELISA test offers excellent limits of detection for the toxin Ergotamine at 1ppb.
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